MACRENE actives

Introducing the cleanest, most clinically active luxury skin care. Derived from nature, backed by science, driven by results.


Created by Dr. Macrene Alexiades MD, PhD. Practicing Dermatologist. Patent Holding Research Scientist. Environmentalist. And the doctor who wrote the definitive textbooks on lasers and clean beauty, MACRENE actives replaces procedures with clean active ingredients sourced from medicinal botanicals and marine plants.

Scientifically active and clinically proven, MACRENE actives is the leading luxury clean skincare brand founded by renowned dermatologist, scientist and beauty authority Macrene Alexiades, MD, PhD, FAAD, the brand’s mission is to combat skin aging and render aesthetic procedures obsolete. The tightly edited range of hero products is informed by Nobel Prize-winning DNA repair research and employs Dr. Alexiades’ breakthrough work harnessing potent plant actives sourced from the land and the sea.

“You can absolutely reverse the effects of aging
and environmental damage to the skin by
intervening with highly pure, plant-based
ingredients. My work has been clinically proven
and the results are significant.”
– Dr. Alexiades

The collection of transformative daily essentials is developed around the guiding principles of prevention, restoration and treatment. Each product is formulated with over fifty organic power actives, many of which are cultivated on Dr. Alexiades’ organic farm in upstate New York. They are designed to achieve total skin health and youthful vitality by boosting skin longevity, repairing DNA damage, providing exceptional antioxidant support and fortifying the moisture barrier.

Clinical trials have shown Macrene actives products to significantly decrease the appearance of fine lines, wrinkles and blotchy discoloration, and to improve texture, elasticity and skin tone. Rigorous third-party post-market testing certifies
safety and prolonged efficacy, ensuring that the last drop is as potent as the first.

The clean, green, vegan and cruelty-free brand maintains the highest standards in environmentally conscious sustainable practices, from ingredient cultivation and formulation to manufacturing and packaging. Products are formulated by in-house
chemists in Dr. Alexiades’ own laboratory.

MACRENE actives commits 10% of profits to charitable endeavors and is proud to underwrite unrestricted educational and research grants for rising scientists at Harvard University and to support environmental concerns.

Our formulas are based on potent actives sourced from medicinal plants isolated in the lab and intensified to deliver your own natural beauty. All are ethically sourced and many are certified organic by USDA or Third Party in EU.

MACRENE Actives skincare is vegan, gluten-free, cruelty-free and non-GMO. NO Parabens, plastics, Phthalates, Sulfates, Acrylates, Glycols, or fragrance. NO animal or human-derived ingredients or animal testing. 

All MACRENE actives products are packaged in recyclable glass and uncoated paper board printed with vegetal biodegradable inks.

Learn more about the renowned creator, Dr Macrene Alexiades.

Available exclusively at Greenhaus Studio - explore the range or book your Macrene Spa Facial with us today.